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ACP Journal Club

ACP Journal Club summarizes the best new evidence for internal medicine from over 130 clinical journals. Once a bimonthly stand-alone journal, ACP Journal Club is now a monthly feature of Annals of Internal Medicine. Research staff and clinical editors rigorously assess the scientific merit of the medical literature as it is published and a worldwide panel of over 5000 physicians assesses the clinical relevance and newsworthiness of rigorous studies.


2013 ACP Journal Club Articles
18 June 2013 
Review: Inhaled medications vary substantively in their effects on mortality in COPD
18 June 2013 
Mediterranean diets reduced cardiovascular events more than a low-fat diet in high-risk persons
18 June 2013 
Review: Hydroxyethyl starch increases mortality and acute kidney injury in critically ill patients
18 June 2013 
Cangrelor reduced ischemic PCI complications more than clopidogrel without increasing severe bleeding
18 June 2013 
Adding aspirin to clopidogrel worsened outcomes in PCI patients receiving oral anticoagulants
18 June 2013 
Ramipril improved walking times and QOL in peripheral artery disease and intermittent claudication
18 June 2013 
Automated reminders and increasing intense support increased uptake of colorectal cancer screening
18 June 2013 
Adding Na/K citrate to standard hydration reduced CIN in patients having coronary angiography
18 June 2013 
Review: Vitamin and antioxidant supplements do not prevent adverse cardiovascular events
18 June 2013 
Review: Acute geriatric unit care reduces falls, delirium, and functional decline
18 June 2013 
Use of SSRIs during pregnancy was not associated with increased risk for stillbirth or neonatal mortality
18 June 2013 
Review: Case management does not reduce unplanned hospital admissions compared with usual care in older persons
21 May 2013 
Review: In patients with heart failure, β-blockers reduce mortality but do not differ from each other
21 May 2013 
Review: Carvedilol may reduce mortality more than other β1-selective β-blockers in systolic HF
21 May 2013 
An intensive lifestyle intervention increased remission from type 2 diabetes in overweight adults
21 May 2013 
Review: Nutritional supplementation has uncertain effects on patient-important outcomes in COPD
21 May 2013 
Review: Replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality
21 May 2013 
Review: Epidural corticosteroids reduce short- but not long-term leg pain and disability in sciatica
21 May 2013 
Corticosteroid injection worsened recovery and recurrence of tennis elbow; physiotherapy had no effect
21 May 2013 
Prednisolone plus chlorambucil preserved renal function in membranous nephropathy
21 May 2013 
Review: Probiotics reduce Clostridium difficile–associated diarrhea in patients receiving antibiotics
21 May 2013 
Review: Cranberry products do not reduce urinary tract infections in susceptible populations
21 May 2013 
Adding endovascular therapy to t-PA did not improve 90-day survival or functional independence after stroke
21 May 2013 
Review: Blood transfusions are associated with higher mortality than no or restricted transfusions in MI
16 April 2013 
Apixaban reduced recurrence and did not increase major bleeding in previously treated VTE
16 April 2013 
In critically ill adults, supplemental parenteral nutrition reduced nosocomial infections
16 April 2013 
Metformin reduced CV events compared with glipizide in patients with type 2 diabetes and CAD
16 April 2013 
Review: Antibiotics reduce treatment failure in acute chronic obstructive pulmonary disease exacerbations
16 April 2013 
Allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence
16 April 2013 
Cognitive–behavioral therapy improved response and remission at 6 and 12 months in treatment-resistant depression
16 April 2013 
Review: Dipeptidyl peptidase-4 inhibitors do not increase overall adverse events in type 2 diabetes
16 April 2013 
Supplementation with vitamin D did not reduce cartilage volume loss or pain in knee osteoarthritis
16 April 2013 
Review: Serenoa repens does not improve symptom scale scores in benign prostatic hyperplasia
16 April 2013 
A clinical decision-support system with interactive alerts improved CD4 cell count in HIV
16 April 2013 
Review: A dichotomized ABCD2 score has limited ability to predict stroke risk ≤ 90 days after TIA
16 April 2013 
Adding renal dysfunction to CHADS2 did not improve prediction of stroke or systemic embolism in AF
19 March 2013 
Aspirin did not reduce recurrence after a first-ever, unprovoked venous thromboembolism
19 March 2013 
Amoxicillin/clavulanate vs placebo: more exacerbation cures, fewer recurrences in mild-to-moderate COPD
19 March 2013 
Review: Lower rather than higher tidal volume benefits ventilated patients without ARDS
19 March 2013 
Hydroxyethyl starch 130/0.4 and saline did not differ for mortality at 90 days in ICU patients
19 March 2013 
A restrictive transfusion strategy reduced 45-day mortality in patients with acute upper GI bleeding
19 March 2013 
Aliskiren increased adverse events in patients with diabetes and kidney disease who were receiving ACE inhibitors or ARBs
19 March 2013 
PCI using drug-eluting stents had higher mortality than CABG in diabetes and multivessel CAD
19 March 2013 
Review: Continuous glucose monitoring reduces HbA1c more than self-monitoring in type 1 diabetes
19 March 2013 
Parenteral hydration did not improve dehydration or quality of life in advanced cancer
19 March 2013 
Review: Adding corticosteroids to antibiotics improves pain relief in patients with sore throat
19 March 2013 
Review: SSRIs somewhat improve dependence and disability after stroke
19 March 2013 
Scores poorly predict major bleeding (c-statistics ≤ 0.61) during oral anticoagulant therapy
19 February 2013 
In recently postmenopausal women, HRT reduced a composite of death, MI, or heart failure at 10 years
19 February 2013 
Review: Cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment
19 February 2013 
Review: Nonpharmacologic caregiver interventions improve dementia symptoms and caregiver reactions
19 February 2013 
Meta-analysis: Procalcitonin-guided antibiotic therapy reduces treatment failure in acute respiratory infection
19 February 2013 
A 10-year exercise program improved oxygen consumption and quality of life in stable chronic heart failure
19 February 2013 
Review: In systolic heart failure, low-sodium diets increase mortality compared with normal-sodium diets
19 February 2013 
Daily multivitamin supplements did not reduce risk for major CV events over > 10 years in men
19 February 2013 
Review: Corticosteroid plus LABA inhalers, vs LABAs alone, reduce morbidity in COPD
19 February 2013 
Review: Etomidate increased mortality and adrenal insufficiency in adults with sepsis
19 February 2013 
Review: The effect of audit and feedback on guideline adherence and patient outcomes is limited
19 February 2013 
A weighted risk index had moderate ability to predict VTE requiring treatment after outpatient surgery
19 February 2013 
The PLAN score predicted death and severe disability in patients with acute ischemic stroke
15 January 2013 
Review: General health checks in adults do not reduce all-cause, cardiovascular, or cancer mortality
15 January 2013 
Hypoglycemia was associated with increased mortality in ICU patients regardless of glucose control strategy
15 January 2013 
A single screening for type 2 diabetes in high-risk adults did not reduce mortality over 10 years
15 January 2013 
Review: Intensive blood pressure control reduces stroke, but not mortality or MI, in type 2 diabetes
15 January 2013 
Physician-, biomarker-, and symptom-based adjustment of inhaled corticosteroids for asthma had similar effects
15 January 2013 
Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients with memory complaints
15 January 2013 
Clinically indicated and routine replacement of peripheral IV catheters did not differ for phlebitis
15 January 2013 
Intermittent and continuous androgen deprivation did not differ for mortality after radiotherapy for prostate cancer
15 January 2013 
NSAIDs were associated with increased risk for mortality, regardless of time since first MI
15 January 2013 
Review: Case management reduces mortality and HF readmissions in patients with HF
15 January 2013 
Review: Interventions for patient transition from hospital to primary care may improve outcomes
15 January 2013 
A 13-item score based on readily available risk factors predicted risk for 3-year mortality in heart failure
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Copyright © 2013 The American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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