JAMES G. ZIMMER, M.D.; RICHARD DEWEY, M.D.; CHRISTINE WATERHOUSE, M.D., F.A.C.P.; ROGER TERRY, M.D.
Anisotropic lipid material has been observed in the urine sediment of patients with the nephrotic syndrome since the early 1900s. These globular anisotropic bodies have the well known "Maltese cross" appearance when viewed with a polarizing microscope. This appearance of certain spherical bodies in a liquid medium has caused them to be classified, since about 1905, as "fluid spherocrystals" or "spherulites," and they are felt to be pure crystalline substances in a phase intermediate between the fluid and the crystalline states.1
Most of the studies concerning the localization and chemical nature of anisotropic lipids are to be found in
ZIMMER JG, DEWEY R, WATERHOUSE C, TERRY R. THE ORIGIN AND NATURE OF ANISOTROPIC URINARY LIPIDS IN THE NEPROTIC SYNDROME12. Ann Intern Med. ;54:205–214. doi: 10.7326/0003-4819-54-2-205
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Published: Ann Intern Med. 1961;54(2):205-214.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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