GEORGE C. GRIFFITH, M.D., F.A.C.P.; H. THOMAS NORRIS, M.D.
Although calcific aortic stenosis is generally accepted to be a late sequela of rheumatic fever, several factors suggest that rheumatic fever may not be the sole or even the principal cause of the valvular deformity. First, a history of joint disease is present in only 20 to 30% of patients with aortic stenosis. Second, the valvular lesion is usually more severe than would be expected if rheumatic fever were the cause. Third, the reported sex incidence (three male patients to each female patient) is not what would be anticipated if rheumatic fever were responsible, inasmuch as rheumatic fever is rather
GRIFFITH GC, NORRIS HT. IS BRUCELLOSIS IMPLICATED IN CALCIFIC AORTIC VALVULAR STENOSIS?1. Ann Intern Med. ;54:254–256. doi: 10.7326/0003-4819-54-2-254
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Published: Ann Intern Med. 1961;54(2):254-256.
Cardiology, Infectious Disease, Valvular Heart Disease.
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