STANLEY L. WALLACE, M.D., F.A.C.P.
Colchicine is an effective drug in the treatment of acute gout. It has diagnostic as well as therapeutic value. Nevertheless, gastrointestinal side effects—hyperperistalsis, diarrhea, nausea, and vomiting—occur in almost all patients to whom therapeutically sufficient colchicine has been given. Other much less frequent but more serious toxic manifestations from relatively small doses have been reported, including agranulocytosis and bone marrow depression,1 loss of hair,1, 2 neurologic damage,3 and death.4
Other colchicine analogs have been introduced in the treatment of acute gout in the hope of separating the therapeutic and toxic effects of colchicine. Desacetylmethylcolchicine was the first colchicine analog to
WALLACE SL. TRIMETHYLCOLCHICINIC ACID IN THE TREATMENT OF ACUTE GOUT12. Ann Intern Med. ;54:274–279. doi: 10.7326/0003-4819-54-2-274
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Published: Ann Intern Med. 1961;54(2):274-279.
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