THOMAS KILLIP III, M.D.; NELSON D. HOLMQUIST, M.D.
Aneurysmal dilatation of the ascending aorta and aortic sinuses with cystic degeneration in the media are well recognized manifestations of Marfan's syndrome.1 The relentless progression of the aortic insufficiency which accompanies and, indeed, aggravates the medial change, and the frequent occurrence of acute aortic dissection have stimulated several surgical attempts at correction. Insertion of a prosthetic (Hufnagel) valve, ligation of the aortic annulus, partial excision of the aneurysm, and wrapping of the aorta with plastic, have been reported.1-3 Despite these surgical attempts, there has been little histologic information about the response of the aorta burdened with medial cystic necrosis to
KILLIP T, HOLMQUIST ND. AORTIC SURGERY IN MARFAN'S SYNDROME. HEMODYNAMIC AND HISTOLOGIC RESPONSE1. Ann Intern Med. 1961;54:431–442. doi: 10.7326/0003-4819-54-3-431
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Published: Ann Intern Med. 1961;54(3):431-442.
Cardiology, Hospital Medicine.
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