NATHANIEL UHR, M.D., F.A.C.P.; HARVEY B. BEZAHLER, M.D.
In 1942 Albright, Burnett, Smith, and Parson1 originated the term pseudohypoparathyroidism (PH) to describe a group of patients with round face, short stature, short metacarpals and metatarsals, ectopic ossifications, elevated serum phosphorus and low serum calcium values. What differentiated these patients from persons with idiopathic hypoparathyroidism was their failure to respond with a phosphate diuresis to parenteral administration of parathyroid extract.
Ten years later the designation pseudo-pseudohypoparathyroidism (PPH) was employed by Albright, Forbes, and Henneman2 in describing a 29-year-old woman who had many of the clinical features of PH but in whom the values for serum phosphorus and calcium were
UHR N, BEZAHLER HB. PSEUDO-PSEUDOHYPOPARATHYROIDISM: REPORT OF THREE CASES IN ONE FAMILY(PSEUDO-PSEUDOHYPOPARATHYROIDISM: REPORT OF THREE CASES IN ONE FAMILY*). Ann Intern Med. 1961;54:443–451. doi: 10.7326/0003-4819-54-3-443
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Published: Ann Intern Med. 1961;54(3):443-451.
Endocrine and Metabolism, Metabolic Bone Disorders.
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