ROBERT W. WINTERS, M.D.; ROBERT E. DAVIES, PH.D.
Within the past few years, there has been a remarkable advance in our understanding of the mechanism by which the kidney is able to produce a concentrated urine. The stimulus for this recent burst of progress has been the introduction into the field of a revolutionary new concept: that of the countercurrent osmotic multiplier. In this brief review, an attempt will be made to present the broad outlines of this new theory along with some explanation of its underlying physical principles and a summary of its major supporting evidence. No attempt will be made to treat the whole subject
WINTERS RW, DAVIES RE. THE ROLE OF COUNTERCURRENT MECHANISMS IN URINE CONCENTRATION: A REVIEW1. Ann Intern Med. 1961;54:810–826. doi: 10.7326/0003-4819-54-4-810
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Published: Ann Intern Med. 1961;54(4):810-826.
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