GERALD E. STONE, M.D.; CHRISTINE WATERHOUSE, M.D., F.A.C.P.; ROGER TERRY, M.D.
Hypercalcemia, as one of the manifestations of malignant disease, has become a well recognized phenomenon during recent years. In 1953 Woodard1 reported that about nine per cent of patients with metastases to bones from primary sites other than the prostate showed elevations of total serum calcium. Myers2, 3 has found high serum calcium levels frequently associated with carcinoma of the lung, breast, and kidney, in addition to multiple myeloma and the lymphomas. Other tumors that have been associated with hypercalcemia include malignant lesions of the stomach, cervix, urinary bladder, uterus, tonsils, cartilage, and neuroblastomas. As will be discussed later, the
STONE GE, WATERHOUSE C, TERRY R. HYPERCALCEMIA OF MALIGNANT DISEASE: CASE REPORT AND A PROPOSED MECHANISM OF ETIOLOGY12. Ann Intern Med. ;54:977–985. doi: 10.7326/0003-4819-54-5-977
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Published: Ann Intern Med. 1961;54(5):977-985.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Hematology/Oncology, Nephrology.
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