B. N. La Du Jr., M.D.; W. M. O'Brien, M.D.; V. G. Zannoni, M.D.
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A specific enzymatic method for the determination of homogentisic acid in blood, urine, and tissues has recently been developed in our laboratory. The method has been utilized to study the tissue distribution of homogentisic acid after its intraperitoneal administration to guinea pigs and to study the factors which facilitate the removal of homogentisic acid from the tissues. Within 30 minutes after administration of homogentisic acid, relatively high concentrations were found in skin and cartilage; much lower concentrations were present in liver, muscle, and brain. No significant differences in the distribution were observed in young versus adult animals. The unusual distribution
La Du BN, O'Brien WM, Zannoni VG. Studies on Experimental Alcaptonuria and Ochronosis.. Ann Intern Med. ;54:1046. doi: 10.7326/0003-4819-54-5-1046_1
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Published: Ann Intern Med. 1961;54(5):1046.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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