R. H. Parker, M.D., (Assoc.); W. H. Beierwaltes, M.D., F.A.C.P.,
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Defective organification of iodine has been studied in goitrous cretins and their siblings. We wish to report a genealogy of 90 members of four generations with two related sibships in which seven of 11 children in the one and two of seven children in the other were cretins. Rapid thyroidal uptake and early release of I131, prompt and marked discharge of I131 after KSCN, and the finding of iodide alone on serum and urine chromatography up to 48 hours after 400 µc. of I131 constitute evidence for a defect in thyroidal organification of iodine in these cretins. Five apparently normal
Parker RH, Beierwaltes WH. Inheritance of Defective Organification of Iodine in Familial Goitrous Children.. Ann Intern Med. ;54:1046. doi: 10.7326/0003-4819-54-5-1046_2
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Published: Ann Intern Med. 1961;54(5):1046.
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