P. R. Holt, M.D.; A. S. Cohen, M.D.; K. J. Isselbacher, M.D.
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Whipple's disease was described and originally considered as an intestinal lipodystrophy. Peroral jejunal biopsy and early exploratory laparatomy have led to a more frequent diagnosis during life, and it has become apparent that the disease is systemic with pathologic involvement of lymph nodes, heart, lungs, and other organs. These tissues show a characteristic infiltration by macrophages filled with periodic acid-Schiff staining inclusions which have now been studied in the electron microscope and which reveal a very striking appearance associated with dense virus-like particles. The significance of these findings will be discussed.
It is of importance that while malabsorption is a
P. R. Holt, A. S. Cohen, K. J. Isselbacher. Newer Concepts of Whipple's Disease.. Ann Intern Med. 1961;54:1049. doi: 10.7326/0003-4819-54-5-1049_1
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Published: Ann Intern Med. 1961;54(5):1049.
Celiac Disease and Malabsorption, Gastroenterology/Hepatology, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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