D. L. Gornel, M.D.; L. M. Loewenstein, M.D.; R. G. Lancestremere, M.D.; S. Papper, M.D., F.A.C.P.
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In 1958, one of the authors (S. P.) presented to the Annual Session of the College clinical and experimental observations in patients with Laennec's cirrhosis who were dying with azotemia. Those studies suggested the possibility that the mechanisms of renal failure in these instances is of circulatory origin, rather than a parenchymal lesion.
Among a variety of attempts to alter renal circulation in this condition (characterized in part by decreased blood pressure) we studied the effects on renal excretion of the intravenous and intramuscular administration of the synthetic sympathomimetic amine, metaraminol. Since similar mechanisms might also be operative in patients
Gornel DL, Loewenstein LM, Lancestremere RG, Papper S. Acute Changes in Renal Excretion of Water and Solute in Patients with Laennec's Cirrhosis Induced by the Administration of the Pressor Amine, Metaraminol.. Ann Intern Med. ;54:1063–1064. doi: 10.7326/0003-4819-54-5-1063_3
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Published: Ann Intern Med. 1961;54(5):1063-1064.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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