RUSSELL E. RANDALL JR.; WILLIAM H. TARGGART, M.D.
Acidosis of renal origin is an increased hydrogen ion concentration due to an impairment in the excretion of titratable acid and/or ammonium ion, to an excessive excretion of bicarbonate, or to a combination of these two defects.1-4 While all renal acidosis is presumably tubular in origin, the term "renal tubular acidosis" has come to represent (and will be so used in this text) that syndrome characterized by a hyperchloremic acidosis resulting from marked impairment in the ability to excrete an acid urine.3-15 The latter is significantly out of proportion to any impairment in glomerular filtration, and hence is not associated
RANDALL RE, TARGGART WH. FAMILIAL RENAL TUBULAR ACIDOSIS1. Ann Intern Med. ;54:1108–1116. doi: 10.7326/0003-4819-54-6-1108
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Published: Ann Intern Med. 1961;54(6):1108-1116.
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