JAMES L. TULLIS, M.D., F.A.C.P.
It has been known for more than 50 years that heterologous platelet antibodies can induce experimental thrombocytopenic purpura1-3 and that iso-immune leukocyte antibodies can lead to pyrogenic and urticarial transfusion reactions.4 Yet surprisingly little attempt was made to transfer these concepts to clinical states of leukopenia and thrombocytopenia until Oliva and Burbetta5 in 1944 and Evans et al.6 in 1948 showed in vitro evidence of cytotoxic substances in plasma, and Harrington et al.7 shortly thereafter found profound in vivo thrombocytopenic activity of plasma from a patient with idiopathic thrombocytopenic purpura.
These latter studies were soon followed by the development of
TULLIS JL. THE ROLE OF LEUKOCYTE AND PLATELET ANTIBODY TESTS IN MANAGEMENT OF DIVERSE CLINICAL DISORDERS12. Ann Intern Med. ;54:1165–1180. doi: 10.7326/0003-4819-54-6-1165
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Published: Ann Intern Med. 1961;54(6):1165-1180.
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