Lawrence J. Cheskin, MD
In overweight or obese adults who have recently lost weight, do weight-loss maintenance interventions reduce weight regain?
Randomized controlled trial.
Blinded (outcome assessors).*
4 clinical centers in the United States.
1032 overweight or obese adults 28 to 83 years of age (mean 56 y, 63% women) who had lost ≥ 4 kg in the past 6 months during a group weight-loss program. Inclusion criteria for the weight-loss phase were body mass index 25 to 45 kg/m2, use of medication for hypertension or dyslipidemia, and no active cardiovascular disease. Exclusion criteria were medication-treated diabetes, recent cardiovascular event, medical or psychiatric condition preventing full participation, recent weight loss > 9 kg, recent use of weight-loss drugs, and weight-loss surgery.
Personal-contact intervention (case management approach with monthly telephone support and quarterly meetings with an interventionist) (n = 342); Internet intervention (unlimited access to a Web–based, interactive intervention) (n = 348); or self-directed control condition (printed lifestyle guidelines and brief visit with an interventionist at 12 mo) (n = 342). The 2 active interventions involved the same counseling strategies and dietary and physical activity recommendations.
Change in weight, energy intake, and moderate-to-vigorous physical activity (MVPA).
93% (intention-to-treat analysis).
All 3 groups regained weight, but less was regained in the personal-contact group (Table). The Internet group had less regain than the control group up to 24 months, but the benefit was lost by 30 months. Energy intake did not substantially increase in any group, but MVPA level decreased in all 3 groups (Table).
In overweight or obese adults who had recently lost weight, a personal-contact weight-loss maintenance intervention reduced weight regain more than a self-directed control condition. An Internet intervention provided early but transient benefit.
Personal contact (PC) vs internet (I) weight-loss maintenance interventions vs self-directed control (C) in overweight or obese adults
†CI defined in Glossary. Differences adjusted for baseline level, change during weight-loss phase, age, sex, race, and center.
Lawrence J. Cheskin. A personal-contact weight-loss maintenance intervention reduced weight regain in overweight and obese adults. Ann Intern Med. 2008;149:JC1–4. doi: 10.7326/0003-4819-149-2-200807150-02004
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Published: Ann Intern Med. 2008;149(2):JC1-4.
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