Jacob Korula, MD
In patients with Child-Pugh stage B alcoholic cirrhosis (AC), how does immediate listing for liver transplantation compare with usual care for survival?
Randomized controlled trial (RCT). ClinicalTrials.gov NCT00701792.
Unclear allocation concealment.*
Unclear if blinded.*
13 centers from tertiary referral hospitals in France.
120 patients 18 to 65 years of age (mean age 50 y, 78% men) who had Child-Pugh stage B AC, Béclère model R score < 4.04, recent recovery from Child-Pugh stage C disease, and complicated cirrhosis in the past 3 months. Exclusion criteria included Child-Pugh stages A or C disease, viral hepatitis, cancer, and contraindications to transplantation.
Immediate listing for liver transplantation (n = 60) or usual care (n = 60).
Included overall survival and cancer-free survival.
100% (intention-to-treat analysis).
The immediate-listing and usual-care groups did not differ for overall survival at 5 years (Table). The immediate-listing group had a lower cancer-free survival rate than did the usual-care group (Table).
Immediate listing for liver transplantation did not differ from usual care for overall survival in patients with Child-Pugh stage B alcoholic cirrhosis.
Immediate listing for liver transplantation vs usual care in Child-Pugh stage B alcoholic cirrhosis†
†Abbreviations defined in Glossary. RBR, NNH, and CI calculated from data in article.
Korula J. Immediate listing for liver transplantation did not differ from usual care for overall survival in stage B alcoholic cirrhosis. Ann Intern Med. ;151:JC1–14. doi: 10.7326/0003-4819-151-2-200907210-02014
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Published: Ann Intern Med. 2009;151(2):JC1-14.
Gastroenterology/Hepatology, Liver Disease, Liver Transplantation, Tobacco, Alcohol, and Other Substance Abuse.
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