Michael E. Farkouh, MD
Do patients with diabetes and no history of myocardial infarction (MI) have similar risk for coronary artery disease (CAD) events as patients with previous MI and no diabetes?
Included studies compared risk for CAD events in patients with diabetes and no MI and patients with previous MI and no diabetes. Outcomes were fatal or nonfatal MI.
MEDLINE and EMBASE/Excerpta Medica (to Apr 2007); Cochrane Central Register of Controlled Trials; and references were searched for cohort studies involving ≥ 100 patients with follow-up ≥ 4 years. 13 articles reporting on 14 cohorts (n = 47 361, age 25 to 84 y, 0% to 100% men) met the selection criteria. Mean duration of follow-up was 13 years (range 5 to 25 y). Patients were enrolled at either a cross-sectional point in time (12 cohorts) or at diagnosis of diabetes or first MI (2 cohorts).
Compared with patients with previous MI and no diabetes, those with diabetes and no MI had lower risk for a CAD event (Table).
Patients with diabetes and no history of myocardial infarction (MI) have a lower risk for coronary artery disease events than patients with previous MI and no diabetes.
Risk for fatal or nonfatal myocardial infarction (MI) in patients with diabetes and no history of MI compared with patients with previous MI and no diabetes*
*CI defined in Glossary. Corrected data obtained from author.
Michael E. Farkouh. Review: Diabetes is not a coronary disease equivalent. Ann Intern Med. 2009;151:JC2–6. doi: 10.7326/0003-4819-151-4-200908180-02006
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Published: Ann Intern Med. 2009;151(4):JC2-6.
Cardiology, Coronary Heart Disease, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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