Roland Staud, MD
Is the risk for myocardial infarction (MI) similar between patients with new-onset rheumatoid arthritis (RA) and those with new-onset diabetes mellitus (DM)?
2 inception cohorts (patients with RA and patients with DM) followed for a mean of 4.6 and 3.9 years, respectively. Data were obtained through linkage of national registers.
10 477 persons who developed RA (based on International Classification of Diseases [ICD] codes and dispensed prescriptions of disease-modifying antirheumatic drugs within 1 y before or after diagnosis) and 130 215 persons who developed DM (based on initiation of treatment with oral glucose-lowering drugs or insulin analogues) over a 10-year period were identified from a cohort of all inhabitants of Denmark (n = 4 311 022) ≥ 16 years of age at baseline (Jan 1997). 556 persons developed both RA and DM. Exclusion criteria were cardiovascular disease (CVD) (including MI, stroke, or coronary vascular procedures), previous diagnosis of RA, or DM treatment at baseline.
Age, sex, comorbidity (modified Charlson's comorbidity index), cardioprotective medications, and socioeconomic status.
MI (ICD codes).
Patients with RA and those with DM had a similar increased risk for MI (P for difference 0.64, Table). In analyses stratified by sex and age, women < 50 years of age had the highest risk for MI (Table).
Patients with new-onset rheumatoid arthritis and those with new-onset diabetes mellitus had a similar increased risk for myocardial infarction.
*CI defined in Glossary.
†Analyses adjusted for age, sex, calendar year, cardioprotective medication, comorbid conditions, and socioeconomic status. P = 0.64 for difference between patients with rheumatoid arthritis and diabetes mellitus.
‡Fully adjusted Poisson regression analysis stratified by sex and age tertiles.
Staud R. Patients with rheumatoid arthritis and those with diabetes mellitus had a similar increased risk for myocardial infarction. Ann Intern Med. ;155:JC6–11. doi: 10.7326/0003-4819-155-12-201112200-02011
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Published: Ann Intern Med. 2011;155(12):JC6-11.
Acute Coronary Syndromes, Cardiology, Coronary Heart Disease, Coronary Risk Factors, Diabetes.
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