BRUCE POLSKY, M.D.; JONATHAN W. M. GOLD, M.D.; ESTELLA WHIMBEY, M.D.; JOSÉ DRYJANSKI, M.D.; ARTHUR E. BROWN, M.D.; GERALD SCHIFFMAN, Ph.D.; DONALD ARMSTRONG, M.D.
Eighteen episodes of community-acquired bacterial pneumonia were diagnosed in 13 patients among 336 with the acquired immunodeficiency syndrome (AIDS) cared for at Memorial Sloan-Kettering Cancer Center since 1979. Bacterial pathogens isolated in 16 of 18 episodes were Haemophilus influenzae in 8, Streptococcus pneumoniae in 6, group B streptococcus in 1, and Branhamella catarrhalis in 1. Eight episodes were presumed Pneumocystis carinii pneumonia until cultures obtained at bronchoscopy confirmed a bacterial cause. Specific antibacterial therapy was curative in 16 of 18 episodes; 2 patients died. Given an estimated yearly incidence of pneumococcal pneumonia in the general population of 2.6/1000, 1.09 cases were expected in our patients with AIDS; we saw 6 (p = 0.001), for an attack rate of 17.9/1000. Bacteria associated with B-cell defects should be anticipated when formulating empiric antibiotic therapy, pending a definitive diagnosis, for pulmonary infiltrates in patients with AIDS.
POLSKY B, GOLD JWM, WHIMBEY E, DRYJANSKI J, BROWN AE, SCHIFFMAN G, et al. Bacterial Pneumonia in Patients with the Acquired Immunodeficiency Syndrome. Ann Intern Med. ;104:38–41. doi: 10.7326/0003-4819-104-1-38
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Published: Ann Intern Med. 1986;104(1):38-41.
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