RICHARD J. ABLIN, Ph.D.; JOHN M. BARTKUS, B.S.; MAURICE J. GONDER, M.D.
To the editor: In reference to the recent update on the acquired immunodeficiency syndrome (AIDS) (1) and our earlier letter of possible immunosuppressive factors in blood products (2), we wish to present our further observations.
Our earlier hypothesis (3) suggested that access of immunocompetent cells to the allogeneic enzyme transglutaminase, which is abundant in seminal plasma and present in antihemophilic factor(s) as factor XIII, is the possible common denominator contributing to immunosuppression in homosexuals and hemophiliacs. Accumulating data in our laboratory support this view.
Immunochemical studies have permitted the identification of factor XIII in preparations of factor VIII, and studies
ABLIN RJ, BARTKUS JM, GONDER MJ. Blood Product Immunosuppression and the Acquired Immunodeficiency Syndrome. Ann Intern Med. ;104:130. doi: 10.7326/0003-4819-104-1-130_2
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Published: Ann Intern Med. 1986;104(1):130.
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