Shereen Ezzat, MD; Carey Strom, MD; Shlomo Melmed, MD
Acromegaly results from unrestrained secretion of growth hormone and insulin-like growth factor 1 (IGF-1), usually occurring as a result of a pituitary somatotroph adenoma (1). Of 283 acromegalic patients retrospectively examined, 13 have been reported to have adenocarcinoma of the colon (2). Klein and associates (3) screened 17 patients with acromegaly for colonic lesions. Nine patients were identified with polyps, 5 of whom had adenomatous lesions. These results prompted us to prospectively examine the association of colonic polyps and acromegaly in patients with hypersomatotropism with no other identifiable risk factors for colon neoplasia. We chose complete colonoscopy as our screening
Ezzat S, Strom C, Melmed S. Colon Polyps in Acromegaly. Ann Intern Med. ;114:754–755. doi: 10.7326/0003-4819-114-9-754
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Published: Ann Intern Med. 1991;114(9):754-755.
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