G. Deray, MD; A. Carayon, MD; P. Le Hoang, MD
To the Editors: The mechanism by which cyclosporine induces acute renal vasoconstriction remains unclear. Endothelin is a novel endothelium-derived vasoconstrictor peptide with a potent and sustained effect (1). Cyclosporine drastically increases the level of endothelin in vivo (in the rat) (2) and in vitro (2, 3). Moreover, the renal constrictive effect of cyclosporine is blunted by endothelin antibody both in isolated rat kidney (4) and in vivo in the rat. These data suggest that endothelin may be an important mediator of cyclosporine-induced renal vasconstriction.
We investigated plasma endothelin concentrations in 14 patients (6 men and 8 women) treated with cyclosporine,
Deray G, Carayon A, Le Hoang P. Increased Endothelin Level after Cyclosporine Therapy. Ann Intern Med. ;114:809. doi: 10.7326/0003-4819-114-9-809_1
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Published: Ann Intern Med. 1991;114(9):809.
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