Toshikazu Ushijima, MD; Yoshiaki Ohbayashi, MD; Hiroshi Sato, MD; Akio Urabe, MD
To the Editor: Neutrophil alkaline phosphatase activity sometimes decreases in patients with myelodysplastic syndromes, suggesting a reduced neutrophil function. The number of neutrophils varies in each case, but patients with myelodysplastic syndromes often have various kinds of infections that are probably related to impaired neutrophil function. Recently, recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been produced in large quantities and has been tried as a clinical treatment (1). We have treated a patient with myelodysplastic syndrome by administering rhG-CSF and observed not only an increase in the number of neutrophils but also an increase in the neutrophil alkaline phosphatase score.
Ushijima T, Ohbayashi Y, Sato H, Urabe A. Granulocyte Colony-Stimulating Factor and Neutrophil Alkaline Phosphatase. Ann Intern Med. ;111:91. doi: 10.7326/0003-4819-111-1-91_1
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Published: Ann Intern Med. 1989;111(1):91.
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