PHILIP C. CRAVEN, M.D.; DAVID J. DRUTZ, M.D.; DWIGHT M. WILLIAMS, M.D.; JOHN R. GRAYBILL, M.D.
To the editor: "Combination Antibiotic Therapy of Bacterial Endocarditis" by Sande and Scheid (1) concisely and usefully summarizes several controversial areas in endocarditis treatment. We are concerned, however, that several of the recommendations poorly supported by evidence may lead to widespread use of potentially suboptimal regimens:
Enterococcal Endocarditis, 4 weeks versus 6 weeks: In the absence of a comparative study, it is not clear why Mandell's carefully studied series of 38 patients supporting 6 weeks of therapy ("early, anecdotal, clinical experience and retrospective studies") should be less persuasive than the series of 13 patients and the unpublished communication cited in
CRAVEN PC, DRUTZ DJ, WILLIAMS DM, GRAYBILL JR. Combination Antibiotic Therapy of Bacterial Endocarditis. Ann Intern Med. ;93:376. doi: 10.7326/0003-4819-93-2-376_1
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Published: Ann Intern Med. 1980;93(2):376.
Cardiology, Endocarditis, Infectious Disease.
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