Calvin Hirsch, MD
In elderly patients who report memory complaints to their primary care physicians, does ginkgo biloba extract reduce risk for Alzheimer disease (AD)?
Randomized placebo-controlled trial (GuidAge). ClinicalTrials.gov NCT00276510.
Blinded* (patients, clinicians, and dementia adjudication committee).
Median 5 years. Follow-up after 2 years was < 80%.
712 primary care physicians at clinical research networks, and 25 memory centers in France.
2854 community-living adults ≥ 70 years of age (mean age 76 y, 67% women) who consulted their primary care physicians or a memory center for memory problems, had an identified proxy, and scored > 25 on the Mini-Mental State Examination, < 6 on the Covi Anxiety Scale, and < 15 on a geriatric depression scale. Exclusion criteria included major objective memory impairment; diagnosis of dementia, major depression, or generalized anxiety; or Clinical Dementia Rating > 0.5.
Standardized ginkgo biloba extract, 120 mg twice per day (n = 1419), or placebo (n = 1435).
Probable AD (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and National Institute of Neurological and Communicative Disorders and Stroke—Alzheimer's Diseases and Related Disorders Association criteria). Secondary outcomes included adverse events.
85% at 2 years.
Groups did not differ for AD at years 1 or 2 (Table); for cumulative incidence of AD over 5 years (4.3% vs 5.2%, P = 0.31); or for such adverse events as death, stroke, hemorrhagic events, or cardiac disorders (all P≥ 0.55).
Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients who reported memory complaints to their primary care physicians.
Ginkgo biloba extract vs placebo for incident Alzheimer disease in elderly patients with memory complaints†
†Abbreviations defined in Glossary. RRR, RRI, NNT, NNH, and CI calculated from placebo event rates and hazard ratios in article.
Hirsch C. Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients with memory complaints. Ann Intern Med. ;158:JC7. doi: 10.7326/0003-4819-158-2-201301150-02007
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Published: Ann Intern Med. 2013;158(2):JC7.
Dementia, Geriatric Medicine, Neurology, Prevention/Screening.
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