Skip Navigation
Menu
Letters |18 June 2013

Chlorthalidone Versus Hydrochlorothiazide

James J. DiNicolantonio, PharmD; James H. O'Keefe, MD; Carl J. Lavie, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From Wegmans Pharmacy, Ithaca, New York; Mid America Heart Institute, University of Missouri, Kansas City, Missouri; and John Ochsner Heart and Vascular Institute, Ochsner Clinical School–The University of Queensland School of Medicine, New Orleans, Louisiana.

    Potential Conflicts of Interest: None disclosed.

×
FULL TEXT
TO THE EDITOR:
Dhalla and colleagues (1) state, “As typically prescribed, chlorthalidone in older adults was not associated with fewer adverse cardiovascular events or deaths than hydrochlorothiazide. However, it was associated with a greater incidence of electrolyte abnormalities, particularly hypokalemia.” This observational cohort study is contrary to a meta-analysis of 108 clinical trials, which indicated that reductions in potassium levels were considered equivalent between chlorthalidone and HCTZ when they were used in the dose range between 12.5 and 25.0 mg (2). In addition, data from MRFIT (Multiple Risk Factor Intervention Trial) indicate that chlorthalidone significantly reduces CVEs compared with HCTZ (P < 0.001) (3).
FULL TEXT
PDF
Not Available
Citations
Citation

DiNicolantonio JJ, O'Keefe JH, Lavie CJ. Chlorthalidone Versus Hydrochlorothiazide. Ann Intern Med. ;158:920–921. doi: 10.7326/0003-4819-158-12-201306180-00015

Download citation file:

© 2018

×
Permissions

Published: Ann Intern Med. 2013;158(12):920-921.

DOI: 10.7326/0003-4819-158-12-201306180-00015

1 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2018 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×