Ming-Hua Li, MD, PhD *; Shi-Wen Chen, MD, PhD *; Yong-Dong Li, MD, PhD; Yuan-Chang Chen, MD; Ying-Sheng Cheng, MD, PhD; Ding-Jun Hu, MD; Hua-Qiao Tan, MD, PhD; Qian Wu, MD; Wu Wang, MD; Zhen-Kui Sun, MD; Xiao-Er Wei, MD; Jia-Yin Zhang, MD, PhD; Rui-Hua Qiao, MS; Wen-Hong Zong, MD; Yin Zhang, MD; Wei Lou, MD; Zhi-Yuan Chen, MD; Yu Zhu, MD; De-Rong Peng, MD; Sui-Xin Ding, MD; Xue-Fan Xu, MD; Xu-Hong Hou, MD, PhD; Wei-Ping Jia, MD, PhD *
Acknowledgment: The authors thank Drs. Gen-Ming Zhao and Guo-You Qin (School of Public Health, Shanghai Fu Dan University, Shanghai, China) for their assistance with the statistical analysis of the data during the preparation of this manuscript and Dr. C.S. Zee (Department of Neuroradiology, Keck Hospital of University of Southern California, Los Angeles, California) for editorial assistance.
Grant Support: By National Natural Science Foundation of China (grants 81171440 and 30970793), Twelfth Five-Year National Science and Technology Support Program of China (grants 2011BAI08B14 and 2011BAI08B06), Shanghai Important Subject Fund of Medicine (grants 05III023 and 074119505), and Program for Shanghai Outstanding Medical Academic Leader (grant LJ 06016).
Potential Conflicts of Interest: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0927.
Reproducible Research Statement: Study protocol: The protocol is fully described in the manuscript. Statistical code: Available on request. Data set: Medicare data sets are available to qualified researchers but cannot be released by the investigators.
Requests for Reprints: Yong-Dong Li, MD, PhD, Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai, China 200233; e-mail, firstname.lastname@example.org.
Current Author Addresses: Drs. M.H. Li, S.W. Chen, Y.D. Li, Y.C. Chen, Cheng, Hu, Tan, Wu, Wang, Sun, Wei, J.Y. Zhang, Hou, Jia, and Ms. Qiao: 600 Yi Shan Road, Shanghai, China 200233.
Drs. Zong, Y. Zhang, Lou, and Zhu: 760 Yan Qu Road, Shanghai, China 200435.
Drs. Z.Y. Chen, Peng, Ding, and Xu: 315 An Hua Road, Shanghai, China 200050.
Author Contributions: Conception and design: M.H. Li, S.W. Chen, Y.D. Li, W.P. Jia.
Analysis and interpretation of the data: M.H. Li, Y.D. Li, H.Q. Tan.
Drafting of the article: S.W. Chen, Y.D. Li, J.Y. Zhang.
Critical revision of the article for important intellectual content: M.H. Li, Y.D. Li, J.Y. Zhang, W.P. Jia.
Final approval of the article: M.H. Li, Y.D. Li, W.P. Jia.
Provision of study materials or patients: S.W. Chen, Y.D. Li, Y.S. Cheng, H.Q. Tan, W. Wang, R.H. Qiao, W.H. Zong, Y. Zhang, W. Lou, Z.Y. Chen, Y. Zhu, D.R. Peng, S.X. Ding, X.F. Xu, W.P. Jia.
Statistical expertise: Y.D. Li, X.H. Hou.
Obtaining of funding: M.H. Li, S.W. Chen, Y.D. Li, W.P. Jia.
Administrative, technical, or logistic support: M.H. Li, S.W. Chen, Y.D. Li, Y.S. Cheng, W.P. Jia.
Collection and assembly of data: S.W. Chen, Y.D. Li, Y.C. Chen, D.J. Hu, H.Q. Tan, Q. Wu, W. Wang, Z.K. Sun, X.E. Wei, W.P. Jia.
The reported prevalence of unruptured cerebral aneurysms (UCAs) varies widely.
To measure the prevalence of UCAs by using 3-dimensional time-of-flight magnetic resonance angiography in adults aged 35 to 75 years.
Cross-sectional study done between June 2007 and June 2011.
Two communities chosen at random from 2 districts (1 urban and 1 suburban) in Shanghai, China.
4813 adults aged 35 to 75 years.
Three-dimensional time-of-flight magnetic resonance angiography, interpreted by 3 observers blinded to the participants’ information, was used to identify the location and size of UCAs and to estimate the overall, age-specific, and sex-specific prevalence.
369 UCAs were found in 336 participants (130 men and 206 women); 4477 participants had no evidence of UCAs. The prevalence was 7.0% overall (95% CI, 6.3% to 7.7%), with 5.5% for men (CI, 4.6% to 6.4%) and 8.4% for women (CI, 7.3% to 9.5%). The overall prevalence of UCAs was higher in women than in men (P < 0.001) and peaked at ages 55 to 64 years in men and women. The UCAs were mostly located in the internal carotid artery (81%), and 90.2% had a maximum diameter less than 5 mm. Mean diameter was larger in women than in men (3.7 mm vs. 3.2 mm; P < 0.009).
Participants were from 2 communities selected from 2 districts in Shanghai, and adults older than 75 years were not studied.
The overall prevalence of UCAs was 7.0% in Chinese adults aged 35 to 75 years, and most lesions had a diameter less than 5 mm.
National Natural Science Foundation of China.
Li M, Chen S, Li Y, Chen Y, Cheng Y, Hu D, et al. Prevalence of Unruptured Cerebral Aneurysms in Chinese Adults Aged 35 to 75 Years: A Cross-sectional Study. Ann Intern Med. ;159: 514–521. doi: 10.7326/0003-4819-159-8-201310150-00004
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Published: Ann Intern Med. 2013;159(8): 514-521.
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