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ACP Journal Club |15 April 2014

Review: Nicotine replacement therapy increases CVD events; bupropion and varenicline do not

Kate Rowland, MD, MS

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Mills EJ, Thorlund K, Eapen S, Wu P, Prochaska JJ. Cardiovascular events associated with smoking cessation pharmacotherapies: a network meta-analysis. Circulation. 2014;129:28-41. 24323793

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Cardiology:

Do smoking cessation therapies (nicotine replacement therapy [NRT], bupropion, and varenicline) increase risk for cardiovascular (CV) events?
Included studies assessed NRT (any marketed dose or combination) or licensed doses of bupropion or varenicline for any duration as cessation therapy in smokers and reported CVD events. Outcomes were any CV event and major adverse CV events (MACE) (CV death, nonfatal myocardial infarction, and nonfatal stroke).
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Rowland K. Review: Nicotine replacement therapy increases CVD events; bupropion and varenicline do not. Ann Intern Med. 2014;160:JC2. doi: 10.7326/0003-4819-160-8-201404150-02002

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Published: Ann Intern Med. 2014;160(8):JC2.

DOI: 10.7326/0003-4819-160-8-201404150-02002

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