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ACP Journal Club |17 March 2015

Review: β-blockers do not reduce mortality in myocardial infarction in the reperfusion era

Steven Borzak, MD

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Bangalore S, Makani H, Radford M, et al. Clinical outcomes with beta-blockers for myocardial infarction: a meta-analysis of randomized trials. Am J Med. 2014;127:939-53. 24927909

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In patients with myocardial infarction (MI), do β-blockers reduce mortality?
Included studies compared β-blockers with control (other active treatment, no treatment, or placebo) in patients with MI. Studies that compared β-blockers with other β-blockers or investigated post-MI heart failure/left ventricular (LV) systolic dysfunction were excluded. Outcomes were all-cause mortality, cardiovascular (CV) mortality, sudden death, recurrent MI, angina pectoris, heart failure, cardiogenic shock, stroke, and drug discontinuation.
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Borzak S. Review: β-blockers do not reduce mortality in myocardial infarction in the reperfusion era. Ann Intern Med. ;162:JC3. doi: 10.7326/ACPJC-2015-162-6-003

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Published: Ann Intern Med. 2015;162(6):JC3.

DOI: 10.7326/ACPJC-2015-162-6-003

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