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Letters |7 July 2015

Calibration and Discrimination Among Multiple Cardiovascular Risk Scores in a Modern Multiethnic Cohort

Andrew P. DeFilippis, MD, MSc; Rebekah Young, PhD; Michael J. Blaha, MD, MPH

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The study cited by Dr. Goff and colleagues (1) shows an association between CAC score and medication use, not an association with decreased events. As the authors acknowledge in the guideline (with the tepid grade IIb recommendation for CAC testing), evidence for a direct effect of CAC scoring on hard outcomes is limited (2). For CAC scoring to explain the overestimation of the risk for ASCVD, the reporting of CAC scores in MESA would have had to prevent almost one half of all ASCVD events predicted by the AHA-ACC-ASCVD risk score.
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DeFilippis AP, Young R, Blaha MJ. Calibration and Discrimination Among Multiple Cardiovascular Risk Scores in a Modern Multiethnic Cohort. Ann Intern Med. 2015;163:68–69. doi: 10.7326/L15-5105-2

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Published: Ann Intern Med. 2015;163(1):68-69.

DOI: 10.7326/L15-5105-2

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