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ACP Journal Club |17 November 2015

After treating unprovoked PE with VKAs for 6 months, warfarin for 18 more months reduced a composite of VTE or major bleeding

Randolph J. Lipchik, MD

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Couturaud F, Sanchez O, Pernod G, et al; PADIS-PE Investigators. Six months vs extended oral anticoagulation after a first episode of pulmonary embolism: the PADIS-PE randomized clinical trial. JAMA. 2015;314:31-40. 26151264

Hospitalists:

Hematol/Thrombo:

Pulmonology:

After a first pulmonary embolism (PE) treated with vitamin K antagonists (VKAs) for 6 months, what are the benefit and harms of 18 more months of warfarin treatment?
Randomized placebo-controlled trial (Prolonged Anticoagulation During Eighteen Months vs Placebo After Initial Six-month Treatment for a First Episode of Idiopathic Pulmonary Embolism [PADIS-PE] study). ClinicalTrials.gov NCT008740883.
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Lipchik RJ. After treating unprovoked PE with VKAs for 6 months, warfarin for 18 more months reduced a composite of VTE or major bleeding. Ann Intern Med. ;163:JC6. doi: 10.7326/ACPJC-2015-163-10-006

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Published: Ann Intern Med. 2015;163(10):JC6.

DOI: 10.7326/ACPJC-2015-163-10-006

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