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ACP Journal Club |20 December 2016

In type 1 diabetes, adding liraglutide to insulin increased hypoglycemia and hyperglycemia with ketosis

Michael Tanner, MD

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Mathieu C, Zinman B, Hemmingsson JU, et al. Efficacy and safety of liraglutide added to insulin treatment in type 1 diabetes: The ADJUNCT ONE treat-to-target randomized trial. Diabetes Care. 2016;39:1702-10. 27506222

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Endocrinology:

In patients with type 1 diabetes mellitus, does adding liraglutide to treat-to-target insulin treatment improve glycemic control?
Randomized placebo-controlled trial (ADJUNCT ONE Treat-To-Target Randomized Trial). ClinicalTrial.gov NCT01836523.
Concealed.*
Blinded* (patients, clinicians, {and study coordinators}†).
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Tanner M. In type 1 diabetes, adding liraglutide to insulin increased hypoglycemia and hyperglycemia with ketosis. Ann Intern Med. ;165:JC64. doi: 10.7326/ACPJC-2016-165-12-064

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Published: Ann Intern Med. 2016;165(12):JC64.

DOI: 10.7326/ACPJC-2016-165-12-064

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2016 American College of Physicians
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