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ACP Journal Club |16 May 2017

In C difficile infection, adding IV bezlotoxumab to standard antibiotics reduced recurrence at 12 weeks

Fred Arthur Zar, MD

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Wilcox MH, Gerding DN, Poxton IR, et al; MODIFY 1 and MODIFY II Investigators. Bezlotoxumab for prevention of recurrentClostridium difficileinfection. N Engl J Med. 2017;376:305-17. 28121498

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Gastroenterology:

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In patients with Clostridium difficile infection (CDI), does adding bezlotoxumab, with or without actoxumab, to standard antibiotics reduce risk for recurrence?
Pooled analysis of 2 randomized placebo-controlled trials (MODIFY I and II). ClinicalTrials.gov NCT01241552 and NCT01513239.
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Zar FA. In C difficile infection, adding IV bezlotoxumab to standard antibiotics reduced recurrence at 12 weeks. Ann Intern Med. ;166:JC53. doi: 10.7326/ACPJC-2017-166-10-053

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Published: Ann Intern Med. 2017;166(10):JC53.

DOI: 10.7326/ACPJC-2017-166-10-053

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2017 American College of Physicians
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