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ACP Journal Club |20 June 2017

In severe aortic stenosis with intermediate surgical risk, TAVR was noninferior to SAVR for death or disabling stroke

Frederick A. Spencer, MD; Gordon H. Guyatt, MD

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Reardon MJ, Van Mieghem NM, Popma JJ, et al; SURTAVI Investigators. Surgical or transcatheter aortic-valve replacement in intermediate-risk patients. N Engl J Med. 2017;376:1321-31. 28304219

Cardiology:

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In patients with severe symptomatic aortic stenosis and intermediate surgical risk, is transcatheter aortic valve replacement (TAVR) noninferior to surgical aortic valve replacement (SAVR)?
Randomized, controlled, noninferiority trial (Surgical Replacement and Transcatheter Aortic Valve Implantation [SURTAVI] trial). ClinicalTrials.gov NCT01586910.
Concealed*.†
Unblinded.†
2 years.
87 centers in the USA, Europe, and Canada.
1746 patients (mean age 80 y, 57% men) who had symptomatic, severe aortic stenosis and intermediate surgical risk (estimated 30-d risk for surgical death 3% to 15% based on Society of Thoracic Surgeons Predicted Risk of Mortality and coexisting illnesses, frailty, and disability).
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Spencer FA, Guyatt GH. In severe aortic stenosis with intermediate surgical risk, TAVR was noninferior to SAVR for death or disabling stroke. Ann Intern Med. ;166:JC68. doi: 10.7326/ACPJC-2017-166-12-068

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Published: Ann Intern Med. 2017;166(12):JC68.

DOI: 10.7326/ACPJC-2017-166-12-068

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2017 American College of Physicians
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