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Letters |21 November 2017

Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus

Susan J. Bersoff-Matcha, MD; Kelly Cao, PharmD; Mihaela Jason, PharmD; S. Christopher Jones, PharmD, MS, MPH; Allen Brinker, MD, MS

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Dr. Mahale and colleagues postulate that HDV infection may have contributed to HBV reactivation in cases identified in our cohort. However, in our case series, there were no reports of HDV infection in either the U.S. Food and Drug Administration Adverse Event Reporting System database or the literature that we reviewed. A limitation of the database is that data may be missing, so we do not know whether results of serologic testing for HDV infection were negative or whether testing was not done. Therefore, we cannot exclude HDV co-infection as a contributing factor in HBV reactivation from the case reports from the database.
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Bersoff-Matcha SJ, Cao K, Jason M, Jones SC, Brinker A. Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus. Ann Intern Med. ;167:760. doi: 10.7326/L17-0477

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Published: Ann Intern Med. 2017;167(10):760.

DOI: 10.7326/L17-0477

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2017 American College of Physicians
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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