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ACP Journal Club |17 April 2018

In perfusion imaging–selected acute ischemic stroke, thrombectomy at 6 to 16 hours improved functional outcomes

Omar Damji, MSc, MD; Eddy Lang, MD

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Albers GW, Marks MP, Kemp S, et al; DEFUSE 3 Investigators. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med. 2018;378:708-18. 29364767

Emergency Med:

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In acute ischemic stroke with potentially reversible ischemic brain tissue, does adding endovascular thrombectomy to standard medical therapy 6 to 16 hours after onset improve 90-day functional outcomes?
Randomized controlled trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke [DEFUSE 3] trial). ClinicalTrials.gov NCT02586415.
Concealed.*
Blinded* (outcome assessors).
90 days. Trial recruitment was stopped early for apparent benefit (prespecified efficacy boundary exceeded).
38 centers in the USA.
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Damji O, Lang E. In perfusion imaging–selected acute ischemic stroke, thrombectomy at 6 to 16 hours improved functional outcomes. Ann Intern Med. ;168:JC42. doi: 10.7326/ACPJC-2018-168-8-042

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Published: Ann Intern Med. 2018;168(8):JC42.

DOI: 10.7326/ACPJC-2018-168-8-042

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2018 American College of Physicians
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