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Letters |17 April 2018

Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials

Shinkan Tokudome, MD; Ryosuke Ando, MD; Shuji Hashimoto, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • Laboratory of Cancer Epidemiology and Prevention, Nisshin, Japan (S.T.)
    Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan (R.A.)
    Fujita Health University School of Medicine, Toyoake, Japan (S.H.)

    Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L17-0737.

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TO THE EDITOR:
Tsodikov and colleagues (1) seem to have resolved a long-standing controversy about the effectiveness of PSA-based screening for mortality reduction in prostate cancer—namely, the discrepancy between the ERSPC (2) and PLCO (3). They did so by applying the same analysis method (Cox regression analysis) to MLTs. Screening translated to an estimated prostate cancer mortality reduction between 25% and 31% in the ERSPC population and 27% and 32% in the PLCO population compared with no screening.
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Tokudome S, Ando R, Hashimoto S. Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials. Ann Intern Med. 2018;168:608. doi: 10.7326/L17-0737

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© 2018

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Published: Ann Intern Med. 2018;168(8):608.

DOI: 10.7326/L17-0737

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2018 American College of Physicians
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