WILLY F. PIESSENS, M.D.
Persons infected with lymph dwelling filarial nematodes such as Wuchereria bancrofti and Brugia malayi may be completely asymptomatic or can present a wide spectrum of clinical manifestations, including chronic elephantiasis, hydrocoeles, and chyluria (1). According to a long standing concept, immune reactions against filarial worms mediate the pathologic changes that appear clinically. Recurrent episodes of acute adenitis and retrograde lymphangitis are thought to be due to immediate-type hypersensitivity reactions to developing larvae or materials released by living adult worms, or both, whereas chronic "obstructive" filarial disease is said to result from delayed-type hypersensitivity reactions to dead or dying adult worms
PIESSENS WF. Lymphatic Filariasis in Humans: An Immunologic Maze. Ann Intern Med. ;95:778–779. doi: 10.7326/0003-4819-95-6-778
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Published: Ann Intern Med. 1981;95(6):778-779.
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