J. FONT, M.D.; B. NOMDEDEU, M.D.; F. MARTINEZ-OROZCO, M.D.; M. INGELMO, M.D.; A. BALCELLS, M.D.
To the editor: Thrombocytopenia with decreased marrow megakaryoctyes as a pure hematologic syndrome is a rare clinical event that has been the subject of an article in your journal (1). The authors state that the differential diagnosis of this syndrome includes hereditary and acquired aplastic anemia, preleukemia, and systemic lupus erythematosus. We describe a patient with reversible drug-related thromocytopenia showing selective absence of marrow megakaryocytes.
An 80-year-old white man had several costal fractures as a result of thoracic traumatism. As an analgesic a commercial combination of oxyphenbutazone and acetaminophen (paracetamol) was prescribed. The patient received it continously for 20 days
FONT J, NOMDEDEU B, MARTINEZ-OROZCO F, INGELMO M, BALCELLS A. Amegakaryocytic Thrombocytopenia and an Analgesic. Ann Intern Med. ;95:783. doi: 10.7326/0003-4819-95-6-783_2
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Published: Ann Intern Med. 1981;95(6):783.
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