ALFRED E. KOEHLER, M.D., PH.D.; EMANUEL WINDSOR, M.S.
The diminution or absence of hydrochloric acid in the stomach is not an infrequent occurrence. Among representative studies are those of Bennett and Ryle,1 who in 1921 observed that 4 per cent of 100 normal, healthy male medical students had achlorhydria, and those made by Vanzant, Alvarez and associates2 who in 1932 found achlorhydria in patients without gastric disease in from 25 to 35 per cent between the ages of 60 to 70 years. More recently Ruffin and Dick3 studied the gastric acidity of 2877 patients and found lack of acid in 10 per cent of the total and in
KOEHLER AE, WINDSOR E. THE EFFECTIVENESS OF REPLACEMENT THERAPY IN ACHLORHYDRIA1. Ann Intern Med. ;18:182–192. doi: 10.7326/0003-4819-18-2-182
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Published: Ann Intern Med. 1943;18(2):182-192.
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