WILLIAM A. WINN, M.D.; CLARA L. HUGHES, M.D.; JEWELL M. SANDERS, M.D.
The following case report of recovery from subacute bacterial endarteritis is presented because it marks the successful application of the treatment of this usually fatal infection by combined sulfapyridine and heparin therapy. The first announcement of this ingenious combination treatment was made by Kelson and White in 1939.1 With the publication of further controlled studies2 a definite feeling of optimism begins to appear in the medical attitude toward the unfortunate patient afflicted with an endocardial or endarterial infection due to Streptococcus viridans (alpha type). In the case herein reported there was the further factor of a tuberculous infection manifested by
WINN WA, HUGHES CL, SANDERS JM. SUBACUTE BACTERIAL ENDARTERITIS COMPLICATING PATENT DUCTUS ARTERIOSUS: CASE REPORT WITH RECOVERY FOLLOWING SULFAPYRIDINE-HEPARIN THERAPY1. Ann Intern Med. ;18:242–250. doi: 10.7326/0003-4819-18-2-242
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Published: Ann Intern Med. 1943;18(2):242-250.
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