The need for huge quantities of human plasma in the treatment of war injuries has naturally stimulated the search for material from some foreign species of animal which would serve as a suitable substitute. It has been shown in human as well as animal experiments that serum or plasma of the horse or cow is effective in the treatment of shock in individuals who tolerate it. The risk of immediate serious reactions, however, as well as its property of sensitizing individuals to future injections, preclude the use of unaltered foreign serum or plasma.
Wangensteen and associates1 have reported a study
POSSIBLE SUBSTITUTES FOR HUMAN PLASMA. Ann Intern Med. 1943;18:251–254. doi: 10.7326/0003-4819-18-2-251
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Published: Ann Intern Med. 1943;18(2):251-254.
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