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Editorials |17 June 2008

Sequential Therapy for Helicobacter pylori: A Worthwhile Effort for Your Patients

Barry Marshall, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Potential Financial Conflicts of Interest: None disclosed.
Requests for Single Reprints: Barry Marshall, MD, The University of Western Australia, School of Biomedical, Biomolecular, and Chemical Sciences, Microbiology & Immunology, H. pylori Laboratory, Room 2.13 L Block, Queen Elizabeth II Medical Centre, Nedlands 6009, Australia.
  • From The University of Western Australia, School of Biomedical, Biomolecular, and Chemical Sciences, Microbiology & Immunology, H. pylori Laboratory, Nedlands 6009, Australia.
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Sequential therapy for Helicobacter pylori refers to the idea of adding more antibiotics to the treatment regimen but giving them in sequence rather than giving all 4 drugs together. Typically, this involves an initial 5-day therapy with a benign combination (for example, pantoprazole, 40 mg, with amoxicillin, 1 g, twice daily) followed by 5 days of 2 further antibiotics plus a proton-pump inhibitor (PPI) (for example, clarithromycin, 500 mg, and tinidazole, 500 mg, plus pantoprazole, 40 mg, twice daily), as shown below:
 
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Marshall B. Sequential Therapy for Helicobacter pylori: A Worthwhile Effort for Your Patients. Ann Intern Med. 2008;148:962–963. doi: 10.7326/0003-4819-148-12-200806170-00227

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Published: Ann Intern Med. 2008;148(12):962-963.

DOI: 10.7326/0003-4819-148-12-200806170-00227

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