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These writers have studied the elastic tissue of the heart wall at different ages. They find that with increasing age, without other cardiac or other vascular lesions, there is an increase in the amount of elastic tissue in the different layers of the heart wall. In cases of arteriosclerosis in which the heart wall is damaged as the result of nutritional disturbances, the connective tissue of the epicardium, myocardium and endocardium increases in amount, the increase being characterized by the appearance of large quantities of elastic tissue. The amount of elastic tissue appears to be directly proportional to the damage
Dynamics of Histogenesis in Cardiac Repair. The Role Played by Connective Tissue.. Ann Intern Med. ;1:114. doi: 10.7326/0003-4819-1-2-114_1
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Published: Ann Intern Med. 1927;1(2):114.
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