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Mellanby found that the injection of bile of an adequate reaction into the duodenum of the cat stimulates the pancreas, and that this was the case after ligation of the pylorus and bile ducts, and after atropine and ergotamine. He suggested that bile is the intestinal stimulus of pancreatic secretion, functioning by causing the elaboration and absorption of secretin. However, in his experiments bile may have caused stimulation by a local nervous mechanism that is not acted on by atropine or ergotamine. The present work was done on dogs. The investigators found that bile by stomach tube stimulates pancreatic secretion
On Bile Stimulation of Pancreatic Secretion.. Ann Intern Med. ;1:114–115. doi: 10.7326/0003-4819-1-2-114_2
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Published: Ann Intern Med. 1927;1(2):114-115.
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