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The introduction by Minot and Murphy of liver diet in the treatment of pernicious anemia has supplied experimental medicine with a hitherto unequalled method of studying blood formation. Three general types of anemia have been produced experimentally, secondary anemia due to hemorrhage, the aplastic anemia due to the destruction of the blood forming elements in the bone marrow and the hyperchromatic anemia produced by certain poisons. The fact which differentiates the condition in pernicious anemia from the types of anemia that have been experimentally produced, is that in pernicious anemia a blood is available which shows a low spontaneous regenerative
Analysis of Morphological Blood Changes in Pernicious Anemia Following Administration of Liver.. Ann Intern Med. ;1:439–440. doi: 10.7326/0003-4819-1-6-439
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Published: Ann Intern Med. 1927;1(6):439-440.
Gastroenterology/Hepatology, Hematology/Oncology, Liver Disease, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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