The work was undertaken for the purpose of determining: (1) The appearance of early pathologic - histological lesions caused by lead carbonate in the guinea pig kidney, (2) The quantity of lead carbonate required to produce demonstrable lesions, and (3) The length of time required for the appearance of these changes.
This investigation was thought necessary, because, as will be seen from the literature, there is a large number of authors, whom I put in the second group, who state that the primary renal lesions in lead poisoning are vascular, and only a few authors (Von Leyden, Legge and
PEJIC' S. The Nature of the Primary Renal Lesion Produced by Lead1. Ann Intern Med. ;1:577–604. doi: 10.7326/0003-4819-1-8-577
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Published: Ann Intern Med. 1928;1(8):577-604.
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