EDGAR V. ALLEN, M.D.; NELSON W. BARKER, M.D.
In Studies I and II methods were suggested which were believed essential for a comprehensive survey of the effects of phenylhydrazine. In brief these are: the effect on the blood, the effect on the function of the liver and kidneys, the effect on erythropoiesis, and the pathologic changes induced by prolonged administration of phenylhydrazine in doses sufficient to affect the erythrocytes which is comparable to that produced clinically. Criticism of conclusions drawn from previous work was that they were not based on results following experimental dosage comparable to that used clinically, and that results following the use of compounds allied
ALLEN EV, BARKER NW. Experiments With Phenylhydrazine: III. Pathologic Anatomy1. Ann Intern Med. ;1:683–693. doi: 10.7326/0003-4819-1-9-683
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Published: Ann Intern Med. 1928;1(9):683-693.
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