FRANK R. MENNE, M.D., F.A.C.P.; THOMAS M. JOYCE, M.D., F.A.C.S.; JAMES D. STEWART JR., A.B.
After more than a century of familiarity with the isolation and identification of iodine (Coindet 1820) and a growing knowledge of its natural distribution in plant and animal life, its agency in the physiology of the latter, and man in particular, is as yet not thoroughly understood.
In the accounts of medical practices of the many centuries of the past, are records of the uses of iodine in many body ailments and especially in goiterous enlargements of the neck. Its use in the latter condition gradually became rationalized (1) by the determination of the presence of iodine as a natural
MENNE FR, JOYCE TM, STEWART JD. Clinical and Pathological Evidence of the Influence of Iodine in the Therapy of Primary Hyperthyroidism*†. Ann Intern Med. ;1:912–934. doi: 10.7326/0003-4819-1-11-912
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Published: Ann Intern Med. 1928;1(11):912-934.
Endocrine and Metabolism, Thyroid Disorders.
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