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The effect of liver extract in pernicious anemia may be analyzed from the point of view of the immediate reaction, as well as of the sustained reaction. The immediate reaction includes among other things three distinct morphological features: the normoblastic response, the reticulocyte response and the liberation of the mature erythrocytes. It is a well-established fact that the bone marrow in pernicious anemia is hyperplastic and contains large numbers of erythrocytes in various stages of development. In other words, there appears to be a difficulty in the maturation of the erythrocytes necessary for their discharge from the marrow into the
Effect of Liver Extract on Erythrocytes and Reticulocytes in Normal Individuals.. Ann Intern Med. ;1:1066–1067. doi: 10.7326/0003-4819-1-12-1066
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Published: Ann Intern Med. 1928;1(12):1066-1067.
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